4 blind spots in the confusing debate about red meat 

Get ready to be grilled.

burger red meat
By Clare Collins
on

Judging by some media headlines this week, you’d be forgiven for thinking researchers, clinicians, and the Australian Dietary Guidelines have it all wrong when it comes to eating red and processed meat.

But that’s not the case.

Research Checks interrogate newly published studies and how they’re reported in the media. The analysis is undertaken by one or more academics not involved with the study, and reviewed by another, to make sure it’s accurate.

The World Cancer Research Fund continuously evaluates the evidence. To reduce your risk of bowel cancer, they advise limiting your weekly intake of unprocessed cooked red meat to 350-500g. For processed meat, the advice is to eat little, if any at all.

This is consistent with advice in the Australian Dietary Guidelines to reduce risk of chronic diseases such as heart disease, type 2 diabetes, and some cancers.

So, why all the headlines?

This week’s coverage comes from four systematic reviews published in the journal Annals of Internal Medicine. The four reviews looked at the risk of heart disease, type 2 diabetes, some cancers, and death (during the follow-up period) among those with the highest versus lowest intakes of red and processed meats.

The authors also published recommendations advising that people shouldn’t change their meat-eating habits, implying they shouldn’t cut back on meat. This is in direct opposition to national and international guidelines.

Let’s take a closer look at what the evidence says and how the authors got to their conclusions.

Review 1: heart disease, diabetes, and cancer

This systematic review of 105 existing studies looked at associations between low and high intakes of red and processed meat combined, rates of death during the study follow-up, and getting heart disease, diabetes, and cancer.

When the authors pooled data from all studies, they found lower intakes of red and processed meats were associated with significantly lower relative risks of many conditions, although absolute risks were small.

Relative risk compares disease rates in one group (high meat eaters) to another group (lower meat eaters), while absolute risk takes into account how common the disease or likelihood of dying from the condition is in the first place.

Compared to people who ate the most red and processed meat, people with lowest intakes were:

  • 24% less likely to develop type 2 diabetes
  • 14% less likely to die from heart disease
  • 13% less likely to die from any cause
  • had a 15% lower risk of a non-fatal stroke

Review 2: cancer

This review examined the relationship between intake of red and processed meat, and cancer incidence and death. It included 118 studies from 56 groups of people.

This review looked at the data in a slightly different way. Risk was assessed based on reducing intakes of meat to three servings per week. This level of intake was set based on the authors’ conclusion that people weren’t likely to reduce their intakes below this level. However, it’s unclear exactly how much meat those with “high intakes” consumed.

The results indicated that lower intakes of red meat were associated with a 7% lower risk of death from any cause compared to those with higher intakes. For processed meat, there was an 8% lower risk of dying from any type of cancer and a 23% lower risk of dying from prostate cancer.

Review 3: heart disease, stroke, type 2 diabetes

This systematic review examined the association between red and processed meat, and a lower life-expectancy, heart disease, stroke, and type 2 diabetes. There were 61 studies on 55 cohorts of people.

This review also looked at health risk, with the lowest-intake group consuming three servings a week.

sandwich
It’s best to limit your intake of processed meat as much as you can.

For a lower intake of red meat, there was a 7% lower relative risk of death from any cause, a 10% lower risk of dying from heart disease, a 6% lower risk of stroke, a 7% lower risk for having a heart attack, and a 10% lower risk for developing type 2 diabetes.

For processed meat, a lower intake was associated with an 8% lower risk of dying from any cause, a 10% lower risk for dying of heart disease, a 6% lower risk for having a stroke, a 6% lower risk of having a heart attack, and a 22% lower risk for developing type 2 diabetes.

Review 4: low vs. high intake in randomized trials

This review evaluated the impact of lower — versus higher — red meat intakes on the incidence of heart disease, stroke, diabetes, and cancer outcomes in 12 randomized trials.

Randomized trials are a type of study where one group is given a treatment or intervention at random; the other group is given a different or no intervention, or given usual medical care or advice.

While the researchers identified 12 eligible trials, they were so varied —ranging from having just 32 participants followed for one year, up to over 48,000 women followed over eight years — that it makes the review results almost meaningless.

The recommendation ended up being predominantly based on that one large trial — of postmenopausal women advised to follow a low-fat diet. The authors found no difference in health outcomes when they compared the combined red and processed meat intakes of women in the low-fat group compared to the usual-care group.

What’s the problem?

The studies include a number of shortcomings.

First, red and processed meat were not consistently separated out across the reviews. This is a problem because research shows processed meats increase the risk of health problems from very low intakes. For red meat, health risks don’t increase until a certain threshold. That’s why red and processed meat cannot be considered the same food group.

Second, the researchers decided to exclude cohort studies (where participants are observed over time without any specific intervention) with fewer than 1,000 participants. This means some fairly large studies will have been excluded, which could alter the results.

steak
Yes, you still need to put a limit on steak dinners.

Third, when talking about a small reduction in absolute risk, the researchers don’t acknowledge the potential impact at the population level.

In these studies, the difference in the actual number of diagnosed diseases or deaths was relatively small between those with the lowest meat intakes compared to the highest. This difference ranged from three fewer people per 1,000 people having a stroke, to 15 fewer per 1,000 people dying from any cause.

But a small reduction in disease at the population level can translate to thousands of people not experiencing a particular health condition over time.

Finally, the authors don’t present full diagrams, called Forest Plots, to allow us to see how much individual studies influence the overall results. This would show whether the studies are all having about the same effect, or if the results are due to just one or two particular studies.

How did they come to their conclusions?

While the authors of these reviews used similar data to other international reviews such as that undertaken by the World Cancer Research Fund, a major difference is in how the results are interpreted.

The researchers used an extremely stringent approach to evaluate the quality of the evidence. This led to authors downgrading every outcome to a “low” or “very low” certainty of evidence.

Based on their assessment of the evidence, the authors advised adults to continue their current unprocessed meat and processed meat intakes, which they termed as a “weak recommendation” with “low certainty evidence.”

While the authors question the validity of observational cohort studies, the reality is that long-term randomized controlled trials would be impossible, and unethical to conduct. You can’t assign large numbers of people to a lifetime diet high in processed and red meat versus a low meat diet and then wait for 10 to 20 years or more to see what diseases they get and what they die from.

Poor diets are a leading contributor to chronic disease and need to be addressed with preventative health policies. If all Australians ate like the current dietary guidelines, we could expect to see heart disease drop by 62%, as well as 41% less type 2 diabetes, 34% fewer strokes, and 22% less bowel cancer. – Clare Collins

Blind peer review

This is a reasonable critique of these reviews and has picked up the fact that the methodology used to assess studies automatically graded the results from cohort trials as low or uncertain. This ignores the fact that large, long-term, well-conducted cohort studies involving over 6 million people have yielded valuable data on dietary patterns and health.

The many criticisms of the reviews include that the authors:

  • Omitted some studies and rejected others such as the Lyon Heart Study because its results seemed to be too good to be true.
  • Excluded studies comparing vegetarian diets with those containing meat.
  • Ignored social, political, and economic factors that influence food selection.
  • Ignored the fact that no diet can be judged on the basis of a single food.

Part of the recommendation was based on their paper which found that most meat-eaters were reluctant to eat less meat and doubted their ability to prepare meals without meat.

The self-appointed panel who did these reviews did not agree on the conclusions, with three out of the 14 recommending a reduction in red and processed meat. Interestingly, only two of the 14 personally consumed more than the amount of red meat recommended in most dietary guidelines.

A previous paper by some of the same authors rejected guidelines that recommend consuming less sugar. On that occasion, four of the five authors declared funding during their study from the International Life Sciences Institute, a major lobby group for processed food companies.


This article was originally published on The Conversation by Clare Collins and reviewed by Rosemary Stanton). Read the original article here.

Media via Shutterstock (1, 2, 3)