Mind and Body

Intermittent fasting: How when you eat affects your mental health

It may not be just what you eat, but when, too.

by Elena Koning and Elisa Brietzke
Originally Published: 
Lithographic plate features a design for a clock, it's hands signifying 8 o'clock, 1928. It appeared...
Transcendental Graphics/Archive Photos/Getty Images

Eating is an essential part of human life and it turns out that not only what we eat but when we eat can affect our brains. Irregular eating times have been shown to contribute to poor mental health, including depression and anxiety, as well as to cardio-metabolic diseases and weight gain.

Fortunately, it is possible to leverage our eating rhythms to limit negative moods and increase mental health. As a doctoral student in the field of neuropsychiatry and a psychiatrist studying nutrition and mood disorders, my team’s research focuses on investigating how eating rhythms change the brain.

Here’s how it all works: The circadian clock system is responsible for aligning our internal processes at optimal times of the day based on cues from the environment such as light or food. Humans have evolved this wiring to meet energy needs that change a lot throughout the day and night, creating a rhythmic pattern to our eating habits that follows the schedule of the Sun.

Although the main clock manages metabolic function over the day-night cycle, our eating rhythms also affect the main clock. Digestive tissues have their own clocks and show regular oscillations in functioning over the 24-hour cycle. For example, the small intestine and liver vary throughout the day and night in terms of digestive, absorptive, and metabolic capacity.

When the main circadian clock in the brain is out of sync with eating rhythms, it affects the brain’s ability to function. Even though the brain is only two percent of our total body mass, it consumes up to 25 percent of our energy and is particularly affected by changes in calorie intake. This means that abnormal meal times are bound to have negative health outcomes.

How food influences mood

Although the underlying mechanisms are still unknown, there is an overlap between neural circuits governing eating and mood. Also, digestive hormones exert effects on dopamine, a neurotransmitter that plays a large role in mood, energy, and pleasure. Individuals with depression and bipolar disorder have atypical dopamine levels. Altered eating rhythms are thought to contribute to mood issues.

There is overlap between the neural circuits governing eating and mood.


Irregular eating may even play a role in the complex underlying causes of mood conditions. For example, individuals with depression or bipolar disorder exhibit disturbed internal rhythms and irregular meal times, which significantly worsen mood symptoms. In addition, shift workers — who tend to have irregular eating schedules — demonstrate increased rates of depression and anxiety when compared to the general population. Despite this evidence, assessing eating rhythms is not currently part of standard clinical care in most psychiatric settings.

Can you optimize eating times?

So, what can be done to optimize our eating rhythms? One promising method we have encountered in our research is time-restricted eating, also known as intermittent fasting.

Time-restricted eating involves restricting the eating window to a certain amount of time during the day, typically four to 12 hours. For example, choosing to eat all meals and snacks in a 10-hour window from 9:00 a.m. to 7:00 p.m. reflects an overnight fasting period. Evidence suggests that this method optimizes brain function, energy metabolism, and the healthy signaling of metabolic hormones.

Time-restricted eating has already been shown to prevent depressive and anxiety symptoms in animal studies designed to model shift work. The antidepressant effects of time-restricted eating have also been shown in humans. Eating on a regular schedule is also beneficial to reduce the risk of health issues such as obesity, diabetes, and cardiovascular disease.

We live in a 24-hour world filled with artificial light and round-the-clock access to food. That makes the effects of disturbed eating rhythms on mental health an important topic for modern life. As more research provides data assessing eating rhythms in individuals with mood conditions, incorporating eating rhythm treatment into clinical care could significantly improve people’s quality of life.

For the general population, it is important to increase public knowledge on accessible and affordable ways to maintain healthy eating. This includes paying attention not only to the content of meals but also to eating rhythms. Aligning eating rhythms with the schedule of the Sun will have lasting benefits for general well-being and may have a protective effect against mental illness.

This opinion article was originally published on The Conversation by Elena Koning and Eliza Brietzke. Read the original article here.

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